Overexpression of neuronal calcium sensor‐1 alters contractile function in adult rat ventricular myocytes
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Characterization of contractile function in diabetic hypertensive cardiomyopathy in adult rat ventricular myocytes.
Diabetes and hypertension both produce myocardial dysfunction that accelerates cardiovascular morbidity and mortality. Coexistence of the two often results in a more severe cardiomyopathy than either process alone. The purpose of this study was to characterize the contractile function of diabetic hypertensive cardiomyopathy at the single myocyte level. Adult spontaneously hypertensive rats (SHR...
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The endothelin (ET) signaling pathway controls many physiological processes in myocardium and often becomes upregulated in heart diseases. The aim of the present study was to investigate the effects of ET receptor upregulation on the contractile function of adult ventricular myocytes. Primary cultured adult rat ventricular myocytes were used as a model system of ET receptor overexpression in th...
متن کاملOverexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes.
Previous studies showed increased phospholemman (PLM) mRNA after myocardial infarction (MI) in rats (Sehl PD, Tai JTN, Hillan KJ, Brown LA, Goddard A, Yang R, Jin H, and Lowe DG. Circulation 101: 1990-1999, 2000). We tested the hypothesis that, in normal adult rat cardiac myocytes, PLM overexpression alters contractile function and cytosolic Ca(2+) concentration ([Ca(2+)](i)) homeostasis in a m...
متن کاملOverexpression of Na/Ca exchanger alters contractility and SR Ca content in adult rat myocytes
XUE-QIAN ZHANG,1 JIANLIANG SONG,1 LAWRENCE I. ROTHBLUM,1 MINGYUE LUN,1 XUJUN WANG,1 FAN DING,1 JEREMY DUNN,2 JONATHAN LYTTON,2 PAUL J. MCDERMOTT,3 AND JOSEPH Y. CHEUNG1 1Weis Center for Research, Geisinger Medical Center, Danville, Pennsylvania 17822; 2Department of Biochemistry and Molecular Biology, University of Calgary Health Sciences Center, Calgary, Alberta, Canada T2N 4N1; and 3Departmen...
متن کاملOverexpression of phospholemman alters contractility and [Ca ]i transients in adult rat myocytes
Song, Jianliang, Xue-Qian Zhang, Lois L. Carl, Anwer Qureshi, Lawrence I. Rothblum, and Joseph Y. Cheung. Overexpression of phospholemman alters contractility and [Ca2 ]i transients in adult rat myocytes. Am J Physiol Heart Circ Physiol 283: H576–H583, 2002. First published May 2, 2002; 10.1152/ajpheart.00197.2002.—Previous studies showed increased phospholemman (PLM) mRNA after myocardial infa...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a1446-a